Research in Social and Administrative Pharmacy
Volume 2, Issue 1 , Pages 96-109, March 2006

A pilot study to describe antidepressant prescriptions dispensed to veterans after stroke

  • L. Douglas Ried, Ph.D.

      Affiliations

    • Rehabilitation Outcomes Research Center (151B), Malcom Randall Veterans Affairs Medical Center, 1601 SW Archer Blvd., Gainesville, FL 32608-1197, USA
    • College of Pharmacy, University of Florida, Gainesville, FL 32610-0496, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 352 376 1611x4969; fax: +1 352 271 4270.
    • ,
  • Michael J. Tueth, M.D.

      Affiliations

    • Department of Psychiatry, Malcom Randall Veterans Affairs Medical Center and Department of Psychiatry, College of Medicine, University of Florida, Gainesville, FL 32608-1197, USA
    • ,
  • Huangang Jia, Ph.D.

      Affiliations

    • Rehabilitation Outcomes Research Center (151B), Malcom Randall Veterans Affairs Medical Center, 1601 SW Archer Blvd., Gainesville, FL 32608-1197, USA

Received 26 August 2005; received in revised form 25 November 2005; accepted 28 November 2005.

Abstract 

Background

Stroke is the third leading cause of death in the United States, following only heart disease and cancer. Approximately 500 000 strokes occur each year in the United States. Patients suffering from poststroke depression have higher rates of morbidity and mortality, slower physical recovery, and lower functional status than stroke patients without depression. Depressed stroke patients may benefit from early treatment with an antidepressant.

Objectives

The objectives of this study were to (1) describe antidepressant-dispensing patterns to veteran patients during the 6-month period before their stroke and 1-year time afterward and (2) examine the association of poststroke antidepressant treatment with mortality.

Methods

Veteran patients (n=543) with one or more hospital discharges during FY2001 with a primary diagnosis of stroke were identified. The discharge date minus the length of stay indicated the index hospitalization date. Antidepressant prescription dispensing records were obtained from the Veterans Integrated System Network 8 Veteran's Affairs (VA) Pharmacy Benefits Management database.

Results

One-third of eligible veteran patients were dispensed one or more antidepressant prescriptions (n=181) either before or after the index hospitalization. Of these veterans, 146 received an antidepressant after the index hospitalization. More than 80% of veteran patients survived the stroke for 1 year or longer (n=448). Among the veteran patients who were discharged from the index hospitalization alive, those with no antidepressant or an antidepressant dispensed only before the stroke had a higher 1 year all cause mortality rate (8.0%) compared with those who were dispensed a prescription for one or more antidepressants afterward (4.8%).

Conclusions

Veterans dispensed an antidepressant after their stroke appeared to have benefited. Opportunities to reduce poststroke sequelae and improve recovery may be lost.

Keywords: Antidepressants, Chronic disease, Depression, Stroke, Veterans, Mortality

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PII: S1551-7411(05)00140-3

doi:10.1016/j.sapharm.2005.11.002

Research in Social and Administrative Pharmacy
Volume 2, Issue 1 , Pages 96-109, March 2006

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